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Intravoxel incoherent motion
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Intravoxel incoherent motion : ウィキペディア英語版
Intravoxel incoherent motion

Intravoxel incoherent motion (IVIM) imaging is a concept and a method initially introduced and developed by Le Bihan et al. to quantitatively assess all the microscopic translational motions that could contribute to the signal acquired with diffusion MRI. In biological tissue, these motions essentially are molecular diffusion of water and microcirculation of blood in the capillary network (perfusion). The concept introduced by D. Le Bihan is that water flowing in randomly oriented capillaries (at the voxel level) mimics a random walk (“pseudo-diffusion” 〔) (Fig.1). It is responsible for a signal attenuation in diffusion MRI, which depends on the velocity of the flowing blood and the vascular architecture. Similarly to molecular diffusion, the effect of pseudodiffusion on the signal attenuation depends on the b value. However, the rate of signal attenuation resulting from pseudodiffusion is typically an order of magnitude greater than molecular diffusion in tissues, so its relative contribution to the diffusion-weighted MRI signal becomes significant only at very low b values, allowing diffusion and perfusion effects to be separated.〔
==Model==
In the presence of the magnetic field gradient pulses of a diffusion MRI sequence, the MRI signal gets attenuated due to diffusion and perfusion effects. In a simple model, this signal attenuation, S/So, can be written as:〔
:\frac = f_\mathrm F_\text + (1- f_\mathrm) F_\text \,

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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